Mosaic Mutant Analysis Identifies PDGFRα/PDGFRβ as Negative Regulators of Adipogenesis.
Sun C, Sakashita H, Kim J, Tang Z, Upchurch GM, Yao L, Berry WL, Griffin TM, Olson LE. Cell Stem Cell. 25:S1934-5909(20)30096-5. 2020 [Link]
Fibroblast-specific Stat1 deletion enhances the myofibroblast phenotype during tissue repair.
Medley SC, Rathnakar BH, Georgescu C, Wren JD, Olson LE. Wound Repair Regen. 2020 [Link]
Buhl EM, Djudjaj S, Klinkhammer BM, Ermert K, Puelles VG, Lindenmeyer MT, Cohen CD, He C, Borkham-Kamphorst E, Weiskirchen R, Denecke B, Trairatphisan P, Saez-Rodriguez J, Huber TB, Olson LE, Floege J, Boor P. Dysregulated mesenchymal PDGFR-β drives kidney fibrosis. EMBO Mol Med. 12(3):e11021, 2020 [Link]
He C, Medley SC, Kim J, Sun C, Kwon HR, Sakashita H, Pincu Y, Yao L, Eppard D, Dai B, Berry WL, Griffin TM, Olson LE. STAT1 modulates tissue wasting or overgrowth downstream of PDGFRβ. Genes Dev. 31(16);1666-1678, 2017 [Link]
Sun C, Berry WL, Olson LE. PDGFRα controls the balance of stromal and adipogenic cells during adipose tissue organogenesis. Development 144:83-94, 2017 [Link]
He C, Medley SC, Hu T, Hinsdale ME, Lupu F, Virmani R, Olson LE. PDGFRβ signalling regulates local inflammation and synergizes with hypercholesterolemia to promote atherosclerosis. Nat. Commun. 6:7770, 2015 [Link]
Iwayama T, Steele C, Dozmorov M, Wren J, Olson LE. PDGFRα signaling drives adipose tissue fibrosis by targeting progenitor cell plasticity. Genes Dev. 29:1106-1119, 2015 [Link]
Zhou H, Feng R, Huang Y, Tripodi J, Najfeld V, Tsankova NM, Jahanshahi M, Olson LE, Soriano P, Friedel RH. Double minute amplification of mutant PDGF receptor a in a mouse glioma model. Science Reports 5:8468, 2015 [Link]
Iwayama T, Olson LE. Involvement of PDGF in fibrosis and scleroderma: recent insights from animal models and potential therapeutic opportunities. Curr Rheumatol Rep. 15:304, 2013 [Link]
Greif DM, Kumar M, Lighthouse JK, Hum J, An A, Ding L, Red-Horse K, Espinoza FH, Olson L, Offermanns S, Krasnow MA. Radial construction of an arterial wall. Dev Cell 23:482-93, 2012 [Link]
Sun Y, Teng I, Huo R, Rosenfeld MG, Olson LE, Li X, Li X. Asymmetric requirement of surface epithelial beta-catenin during the upper and lower jaw development. Dev Dyn 241:663-74, 2012 [Link]
Olson LE, Soriano P. PDGFRbeta signaling regulates mural cell plasticity and inhibits fat development. Dev Cell 20:815-826, 2011 [Link]
Olson LE, Soriano P. Increased PDGFRα activation disrupts connective tissue development and drives systemic fibrosis. Dev Cell 16:303-313, 2009 [Link]
Olson LE, Tollkuhn J, Scafoglio C, Krones A, Zhang J, Ohgi KA, Wu W, Taketo MM, Kemler R, Grosschedl R, Rose D, Li X, Rosenfeld MG. Homeodomain-mediated beta-catenin-dependent switching events dictate cell-lineage determination. Cell 125:593-605, 2006 [Link]
Olson LE, Zhang J, Taylor H, Rose DW, Rosenfeld MG. Barx2 functions through distinct corepressor classes to regulate hair follicle remodeling. Proc Natl Acad Sci USA 102:3708-3713, 2005 [Link]